Taking the Heat: How Frore Systems’ New Cooling Chip Unleashes Your Device’s Power

When Seshu Madhavapeddy first pitched his vision for a new type of computer chip that could cool computing devices, believers were in short supply.

“Most people when they heard our idea would say it’s impossible,” says Madhavapeddy, co-founder and CEO of Frore Systems. “The attitude of some seemed, ‘We won’t believe it even after we see it.’”

People are bound to believe now. Four years after Madhavapeddy and Surya P. Ganti co-founded Frore, the company exited stealth mode and unveiled its new chip, dubbed AirJet. Borrowing ideas from technology used to cool aircraft engines, AirJet generates short, intense blasts of air that target heat, a critical pain point in all computing devices.

“Heat is by far the biggest hurdle we need to overcome in computing,” says Patrick Moorhead, a respected industry analyst and CEO of Moor Insights & Strategy. Heat, or rather the inability to remove it effectively, means that some of the industry’s most powerful processors are often forced to perform at half speed. Frore’s AirJet solid state air-cooling chips could double the speed at which today’s notebooks and tablets can operate, says Moorhead. “I came in a skeptic but now I’m a huge believer.”

Finding a 21st century solution to an old problem

The idea for Frore was first hatched over a beer in San Diego in 2018. Madhavapeddy and Ganti both worked at Qualcomm, where they had just completed work on a new fingerprint sensor Qualcomm had created for smartphones and other devices.

“We were brainstorming about what would be a cool thing to do together if we were to start a company on our own,” Madhavapeddy says. Ganti, who had previously worked as a senior research scientist at GE, a top supplier of jet engines, floated the idea of applying to computers the technique used for cooling aircraft engines. “I immediately latched onto it,” Madhavapeddy says. “The fan was invented in the 19th century, and yet as we move into the 21st century, it still remains the main option for heat removal.”

The faster a processor runs, the more heat it generates. If it can’t be cooled effectively or sufficiently, it risks overheating. Because fans are loud and take up precious space, manufacturers are often forced into a compromise that involves running chips at less than full speed. For example, the ultrafast Apple chip inside the MacBook Air, one of the world’s thinnest notebooks, is often operating at less than 50 percent of its full power. “We saw an opportunity to bring 21st century technology to the problem,” Madhavapeddy says.

A solution inspired by jet engine technology

Madhavapeddy already had two successful startups to his credit. Alcatel-Lucent bought the first company he had co-founded, Spatial Wireless, for $300 million in 2005. The second company, Sipera Systems, was sold for an undisclosed sum to the networking company Avaya in 2011. He was eager to make the leap into his third startup. It took him a while to convince Ganti to give up his vice president of technology job at Qualcomm. But by July 2018, the pair set up shop in Ganti’s garage in Los Altos and started working on Frore, a synonym for frozen and frosty.

Heat is removed from an aircraft engine through a process called jet impingement that creates high velocity blasts of air. “Because the air is moving really fast, it’s a very efficient way of sucking up heat from hot surfaces,” Ganti says. His idea was to bring that same thermal cooling technique to portables and phones. “The question was how would you miniaturize it into a chip 2 millimeters thick,” Ganti says. Their chip, which does physical work by creating high-velocity air flow, is the first of its kind, and its development demanded technological breakthroughs across disciplines. The company’s earliest employees were PhDs from an array of specialties, including electrical engineering, mechanical engineering, materials science, chemistry, and physics.

“We didn’t know exactly how, but we knew that it was within the realm of possibility,” Madhavapeddy says. “And when Surya says something is possible, he is going to find a way.”

New processes require a new chip fab

The pair found an early ally in Navin Chaddha, managing partner at Mayfield. Initially, Madhavapeddy had been seeking only advice from Chaddha, whom Ganti had known for years through the alumni network of the Indian Institute of Technology. Soon, Mayfield was ready to invest so the company could “break the rules of science to be able to do this thing,” Chaddha says.

When Madhavapeddy said he might need $2 million to get Frore going, Chaddha had other ideas. “That’s not interesting because you won’t make any progress as a hardware company,” he remembers saying. “The right raise for you is $10 million.” Mayfield led Frore’s $10 million seed round.

It was a given that the Frore chip had to be tiny. The two believed it would be used like memory chips, where manufacturers—or users—could add more cooling chips just as they can snap in more memory, if desired. They also insisted their invention be silent. “A consumer buying an electronic device wants it to perform at its highest potential, they want it thin, and they want it to be silent,” Madhavapeddy says.

Frore had a prototype one year after they had started. With a design plan in hand, Frore expanded to Taiwan, the world center for semiconductor production facilities.

“Because the materials we use, the process technology we use, is so unique there was no company out there that could take our blueprints and manufacture the chip,” Ganti says. “So we had to build our own fab from the ground up.”

Laptops before smartphones

It took a year before the fab in Taipei could produce samples. Since then, they’ve been perfecting those samples and enduring a marathon process that the industry calls “qualification.” Once fully qualified, Frore fab is ready to produce 1 million AirJet chips per year. Additional capacity is planned in 2024, both through in-house expansion and through licensing to contract manufacturing partners.

As veterans of Qualcomm, a wireless company, it was natural for Madhavapeddy and Ganti to think of going after the smartphone market. But Chaddha persuaded them to focus on a smaller market, at least initially. “The required volume per customer could be 10 million, 50 million, 100 million phones,” Chaddha says. “They were never going to adopt a brand new technology without some proof points.” He suggested they pick an easier point of entry instead, and show demonstrable success. “Then go after the volume opportunity,” he told them. Frore now has a plan to focus initially on the ultra-thin notebook market, then move into the rest of the laptop market, tablets, headsets, and gaming devices—and eventually smartphones.

Working with Mayfield: Trust, Radical Candor, and a Gentle Guiding Hand
Read more >>

From the start, Frore has had good relationships with potential customers. Madhavapeddy has been knocking on customer doors since almost the beginning and has found a receptive audience. “There is such a latent demand and hunger in the market for an innovative thermal solution that truly unleashes the performance of their compute devices,” he says.

Chip makers are interested in any innovation that might help maximize the performance of the processors they produce. Qualcomm is an early investor and partner. Intel has had a year-long deep engineering collaboration, integrating AirJet into the Intel Evo ultra-thin notebook reference platform. “Intel is excited about the engineering collaboration with Frore Systems to help ready their technology for future Intel Evo laptops,” says Josh Newman, VP & GM Mobile Platforms at Intel.

“We have customers who are committed to launching devices with AirJet in the second half of 2023,” Madhavapeddy says. Because of confidentiality agreements he can’t name the companies, but they include, he says, large notebook makers familiar to any consumer.

A quintessential Silicon Valley tale

As Frore made demonstrable progress, more and more skeptics became believers, allowing the company to raise $116 million in venture capital to date. It still has some $70 million in cash as it seeks to win over the market in the months and years ahead.

“Frore Systems represents what Silicon Valley startups are all about,” Chaddha says. “The company has tackled one of the industry’s biggest challenges, delivering products that will completely transform computing.”

October Human & Planetary Health Newsletter

In this edition:

  • Next-Gen Biomanufacturing Company Prolific Machines Launches with $42M to Build the Assembly Line for Biology
  • Mammoth Co-founder & CEO Trevor Martin & Ursheet Share Company Building Learnings on TechCrunch Live
  • Arvind Shares his POV on Planetary Health Investing & What he Looks for in Companies with Axios and BIOS
  • UBCO Partners with Chemix to Create World’s First Ultra-Safe, High-Energy Cobalt-Free Battery
  • Endpoint Health Launches New Precision Immunology Program, Appoints First Chief Medical Officer
  • Mirvie Expands Leadership Team with Appointment of Alison Cowan, M.D. as Head of Medical Affairs

Next-Gen Biomanufacturing Company Prolific Machines Launches with $42M to Build the Assembly Line for Biology

The manufacturing process for cultured meat has historically been difficult and expensive. We are thrilled to partner with the Prolific Machines team as they pioneer a unique manufacturing approach for cultured meat cells and beyond that will transform industries by creating an assembly line for biology. Arvind shares five insights from investing in Prolific below.

Read more >>

Mammoth Co-founder & CEO Trevor Martin & Ursheet Share Company Building Learnings on TechCrunch Live

Mammoth Biosciences CEO & Co-founder Trevor Martin joined Mayfield’s Ursheet at TechCrunch Live for a candid conversation on Mammoth’s inception to iconic journey.  Watch the recording to learn how to create built to last relationships with co-founders and investors, align around the vision and mission, recruit a world-class team, turn an audacious goal into tangible progress, and more.

Watch here >>

Arvind Shares his POV on Planetary Health Investing & What he Looks for in Companies with Axios and BIOS

Arvind sat down with Megan Hernbroth at Axios to share insights into his investment strategies and the future of climate technology. He was also featured in a Q&A by BIOS where he shared advice for founders preparing to fundraise, what he looks for in founders and inception-stage companies, finding product-market-fit in capex heavy companies, and more.

Read more >>

UBCO Partners with Chemix to Create World’s First Ultra-Safe, High-Energy Cobalt-Free Battery

UBCO, the global leader in electric utility vehicles, has partnered with cutting edge AI-powered battery platform Chemix to commercialize sustainable, ultra-safe, and high-energy cobalt-free (Co-free) Li-ion battery technology. Chemix is using AI to develop battery chemistries similar to how AI has been applied to speed up drug development, and this collaboration will help reduce battery dependence on rare earth minerals.

Read more >>

Endpoint Health Launches New Precision Immunology Program, Appoints First Chief Medical Officer

Endpoint Health has acquired Iconic Therapeutics as part of its newest precision immunology program, which aims to transform immune-mediated inflammatory disease treatment with novel precision medicine strategies. The team also welcomed Ransi Somaratne, M.D. as their first Chief Medical Officer to lead the company’s clinical strategy and drug development programs.

Read more >>

Mirvie Expands Leadership Team with Appointment of Alison Cowan, M.D. as Head of Medical Affairs

Mirvie, a pioneer in predicting unexpected pregnancy complications, has welcomed Alison Cowan as Head of Medical Affairs. Dr. Cowan will guide Mirvie’s continued clinical and commercial development of the proprietary Mirvie RNA platform, which is first to predict preeclampsia and preterm birth months before they happen by revealing the underlying biology of each pregnancy.

Read more >>

Naver to Acquire Poshmark

Five Insights From Investing in Prolific Machines

For the past 9 years I have been investing in companies reinventing our supply chain to become carbon negative. I founded IndieBio in 2014, have invested in over 150 companies and helped pioneer the new foods sector, being involved at the inception stages of food companies such as NotCo, Upside Foods, and Prime Roots. When I moved to Mayfield two years ago, I continued my mission to help founders by supporting them from inception to iconic. I thought I was done with cell based meats and food. Turns out, I was wrong. My Mayfield investment journey began by leading Prolific Machines’ $3.1 million seed round and I am excited to share the news of their $42 million total funding from fellow top-tier investors.

Here are five insights I gained from investing in Prolific Machines.

1. All revolutions have two waves

Every technological revolution in history occurs in two broad waves. First comes the innovation wave where the key features and capabilities to disrupt an industry are invented and demonstrated. The second and much larger wave is consolidation, where the innovations are made affordable and accessible to all (if we are to draw these waves to scale, the second wave looks more like a tsunami in terms of historical impact). Then, the cycle repeats, with innovation once again eroding away the advantages of the prior consolidation. We currently sit at the tail end of a 10,000 year consolidation of the food chain, where incremental innovations and consolidations have led to affordable beef, chicken, pork, corn, wheat and a handful of vegetables in every grocery store in the developed world.

A modern cow is a meat factory, producing ribeye and filet for low cost – and it’s remarkably successful. Over 350 million cows are killed every year to feed humanity. 72 billion chickens. 1.3 billion pigs. 345 million tons of meat are produced a year. Over one trillion dollars are earned by meat producers yearly. But this biological factory is outdated and destroying our planet. To feed all the livestock we consume, 20% of all greenhouse gas emissions on the planet is released.

This is remarkable. It’s also unsustainable. So a new class of alternative protein companies were born.

This first wave of revolutions, the innovation wave, has spawned hundreds of alternative protein companies over the past decade and have demonstrated market demand and product features. Plant based foods are ubiquitous but not the same as the real thing. Cell based meats have only been tasted by investors. Making everything harder, the cost of capital has recently risen, eliminating the ability to profitably scale by simply adding more capacity. We have to lower the cost of capacity to get to profitability.

The second wave of revolutions, the consolidation wave, is driven by innovation in production. For millennia, it has boiled down to reinventing the assembly line. Early in the industrial revolution, the spinning jenny enabled one person to do the labor of a hundred by reinventing the method of spinning cotton. Fifty years later, Henry Ford famously created the idea of an assembly line for automobile manufacturing, breaking down the labor into specialized roles while the car moved past them. He created a consolidation wave that collapsed the number of car companies at the time from hundreds to just a handful. Elon Musk took this a step further with casting the Tesla Y chassis in just a few parts. Assembly line innovations create powerful moats. The catch is, it’s hard to invent new assembly lines.

After meeting the Prolific Machines co-founders, Deniz Kent, Max Huisman and Declan Jones, I saw a company that could become the second wave forming on the horizon.

2. Great founders are radical

Great founders are radicalized by a perceived injustice in the world, and build their company to right it. Steve Jobs once remarked to his engineers that every second the computer took to boot up was wasting their users’ lives. As we were getting to know Deniz and his co-founders, we were listing the various applications and business models of their technology. Their eyes would glaze over whenever we strayed from food. Finally I asked, “Why do you keep coming back to cellular agriculture?” Deniz took a breath and began. “When I was a kid, I grew up in southeast Turkey near the border with Iraq, and when the war with Iraq erupted, thousands of refugees flooded our town. I saw the horrors of people on the move, the pain caused by fleeing a bad situation and the lives it upended. I realized that is what will happen globally during climate change and we want to stop that from happening.” He and his co-founders looked at me, steel-eyed.

I immediately realized that the refugees overrunning his town was the very face of climate change to Deniz, the event that radicalized him into action. Deniz told me he worked on vaccines at a large pharma company but realized his background in stem cell research could be used to fight climate change by eliminating animal agriculture and beyond. He then used his power of mission to recruit the top talent needed to execute his vision for the best tasting, lowest cost meat on the planet. The political refugee crisis of Turkey caused Prolific Machines to be born. The incredible talent drawn to the injustice of climate change will help Prolific achieve its goals.

3. Meat production and drug production are the same

The heart of Prolific Machines’ approach to reinventing the assembly line for food is rooted in identifying the most expensive drivers of cell culture. Cost analysis shows that by weight, growth factors are by far the most expensive part of growing food – or anything really – in culture. So Deniz and his team had devised a novel way to eliminate the need for these growth factors in mammalian cell culture. What that means is it would theoretically enable cells to grow at the cost of electricity and basic nutrients like sugar.

Growth factors control the important growth stages of tissue. Image copyright Frontiersin.org

There are many approaches to make growth factors cheaper. But none that I know of to eliminate their need in culture altogether. That is what Prolific was proposing to do (exactly how will be revealed after the final bricks in their patent wall are placed). But if eliminating growth factors is possible, the impact on humanity would be enormous. Meat production and biologic drug production would become the same thing, with different programs for the cells – the same inputs with different outputs. Biology programmed to produce what we need. Meat grown in culture at costs below factory farmed cows. Therapeutics like antibodies and cell therapies could become drastically cheaper, enabling life saving drugs to become affordable around the world. Human breast milk could be made in culture, eliminating baby formula shortages and replacing it with the real thing. Industry after industry, sector after sector could become supercharged with lower price, sustainable ingredients.

4. Thinking big and small

Translating a founder’s true vision and their radicalized self that they hide from the public, potential investors and even their parents, into a working business with milestones that represent the future well enough to create value inflection, is what I love to do. At the inception stage of companies, the seed or even pre-seed rounds, it is not about thinking fast and slow, but thinking big and small.

The big is as hard as the small. Not many VCs want to take risk – meaning career risk – by going after an audaciously large goal. Easier to sleep well at night by doing something achievable. I find the opposite to be true. Everything is hard, everything is risky and nothing is guaranteed. So going after something big enough to matter makes sense. So many founders I meet tell me they didn’t dare share what they really want to do because it scares investors. I am always surprised by that. It’s in the translation from a vastly big idea to the daily tasks where people lose their way.

Navin Chaddha, Mayfield Managing Director, gave me sage advice to be a great inception stage investor. He said, “first you are the management consultant (build the business model), then the recruiter (help hire great people), then the banker (help get them financed).”

With Prolific Machines, I work with the team weekly to help block and tackle the minutia (who is the best IP strategy team?, etc), while helping Deniz to make the big strategic decisions relative to the runway. We hired a phenomenal chief of staff to offload critical work from Deniz. We brought on the best engineers in their field. I had never spent my entire energy on just a few companies, and it was amazing. I realize that networks matter. The better the investors’ networks, the dollars go further, faster because calls get answered.

Our weekly board meetings flew by and the team made fast progress. We kept things very quiet. After a few months, when the first signs that their basic technology could potentially work were replicated, we decided to step on the gas. We needed a large Series A with a great investor who could help our mission. I knew who to call.

Cooper Rinzler, a partner at Breakthrough Energy Ventures, would come by IndieBio and we would imagine solving climate change with lasers and more, pushing the boundaries of what was possible. But the truth was we were bonding over our missions, coming from opposite angles – he from later stage and scaling, me from inception stage and shaping. We always looked for ways to work together. Now at Mayfield, we had the chance. I know Cooper and Breakthrough Energy Ventures have a tight scientific diligence process. They don’t fund vaporware, nor companies with no chance to move the needle. If it can’t truly dent climate change, they pass. As Cooper and BEV dove in I watched Deniz grow. Fast. At Mayfield, there is a saying, “No company can grow faster than its founder.” And it is so true. As we worked in direct mentoring sessions, Deniz absorbed everything, from how to handle a room full of investors to confidentiality and all the soft parts of building trust. The team worked long hours to create an 80 page diligence document. Humbird’s famous whitepaper (a paper that details the scalability problems with cell culture) was invoked and many assumptions tested. Countless hours of meetings and papers written. After a month or two, while Cooper was on a long-planned vacation in Italy, Prolific Machines signed the Series A term sheet. That was now a year ago.

Since then, the Prolific team has grown to over 20, with the world’s best in their subjects moving house and home from around the world to join the team. The company is moving to Emeryville into a 10,000 square foot facility that will include a demo assembly line with the ability to supply the first customer. And a cadre of restaurateurs and celebrities have become involved in the development of Prolific’s food, setting up the future by winning the heart and mind of the public.

5. Zen and the art of company building

The process of company building is repeatable, and over time leads to repeatable outcomes. I learned it out of necessity at IndieBio and Mayfield has refined it to an art form. While getting heavily involved in company building isn’t scalable, it makes my work meaningful.

I read Zen and the Art of Motorcycle Maintenance when I was at Van Nuys High. It profoundly affected me though I didn’t know it at the time. The book is about quality. I recently re-read it. I realized it encapsulated the way I approach investing, and my life. The book explains quality is found in deep participation in our activities. It argues we should understand how a motorcycle is built, runs and is maintained for a quality experience with motorcycles. The same is true for company building. I want to deeply understand the technology of the companies I invest in. I draw pictures and diagrams until I can explain it back to the founders in my own words. I do this because I want to spend a lot of time with these founders and their missions. If I cannot understand the depths of deep technology companies, I couldn’t really help with go-to-market strategy, building business models, or explain to others what they do and why it matters. Diving into each company and helping with hiring, financing and personal growth is where I find quality and joy. This extends to VCs I work with. Po Bronson is the managing director of IndieBio and my friend. He found Prolific Machines, recognizing their potential, and wrote the first check. By diving into the science, he and Cooper came to understand where Prolific could go.

Prolific Machines is an example of the companies I want to invest in. My tombstone I call it. If you etch the companies I invested in on my tombstone and nothing else, that is the legacy I leave. For me, tombstone companies are solving a very specific problem that is holding back progress in a sector that is critical to society to solve. Like food, water, disease, suicide, pain and climate change. I take this very seriously. There are probably only thirty to forty spots left on my tombstone. And every company I invest in I will spend up to 5% of my life with. I meet Deniz weekly and join the all-hands. It helps to see around corners and participate. So money is not the rate limiting resource, it is time. This level of commitment is the same I ask of founders, and a mission worthy of history.

I am honored to be able to spend my time and resources to help the Prolific Machines team on their journey to create the next generation of bio-manufacturing assembly lines, prevent climate change, and one day make history by providing ubiquitous meats people love.

2022 Mid-Year Review – Looking Back, Looking Forward

In the first six months of 2022, we curated conversations with gamechanging entrepreneurs to share company building insights; provided advice for founders navigating a changing and challenging market; marked milestones from our portfolio companies; and strengthened our communities as we were able to meet in person again. Even in challenging times we are ever inspired by entrepreneurs changing the way we live, work and play. Join us as we look back on the first half of 2022 and forward to all the innovation to come.

June Human & Planetary Health Newsletter

In this edition:

  • Mirvie, Pioneer in Predicting Unexpected Pregnancy Complications, Raises $60M
  • Endpoint Health Raises $52M to Expand and Advance Precision Immunology Pipeline
  • Chemix Announces its AI-Powered Battery Platform to Accelerate the Transition to Sustainable Energy
  • Mammoth Co-founder Janice Chen & Endpoint Health Co-founder Diego Rey Share Founder Journey Insights at TechCrunch Early Stage
  • Mammoth CEO Trevor Martin Joins Ursheet Parikh & Arvind Gupta to Share the Hard Truths of Building Engineering Biology Companies
  • VR Meditation Company TRIPP Raises $11M to Build the Mindful Metaverse

Mirvie, Pioneer in Predicting Unexpected Pregnancy Complications, Raises $60M

Unexpected complications affect one in five pregnancies, yet women, expecting parents and doctors lack a reliable way to detect complications before symptoms appear. Mirvie’s new funding will support the continued clinical and commercial development of their proprietary RNA platform, which is the first to predict preeclampsia and preterm birth months before they happen.

Read more >>

Endpoint Health Raises $52M to Expand and Advance Precision Immunology Pipeline

Precision Immunology Platform Endpoint Health is dedicated to addressing unmet needs in immune-mediated acute and chronic diseases. This new funding will be used to expand its therapeutic pipeline to include programs for chronic immune-mediated diseases as well as to advance their precision sepsis therapy to a Phase II clinical trial.

Read more >>

Chemix Announces its AI-Powered Battery Platform to Accelerate the Transition to Sustainable Energy

The movement toward electric transportation and renewable energy is rapidly going mainstream and will hugely impact our planetary health. However, the lithium-ion battery market is heavily supply constrained as new chemistries and better testing processes are required to improve performance and unlock the supply of batteries. We’re thrilled to partner with the Chemix team as they work to save our planet, one sustainable battery at a time

Read more >>

Mammoth Co-founder Janice Chen & Endpoint Health Co-founder Diego Rey Share Founder Journey Insights at TechCrunch Early Stage

How do you evolve from PhD to startup founder and beyond? We recently hosted a series of conversations at TechCrunch Early Stage, including one with Mammoth’s Janice Chen and Endpoint’s Diego Rey, who shared their learnings on how to choose the right co-founders, advice for first-time founders, and more.

Read more >>

Mammoth CEO Trevor Martin Joins Ursheet Parikh & Arvind Gupta to Share the Hard Truths of Building Engineering Biology Companies

Mammoth CEO Trevor Martin joined Mayfield’s Ursheet Parikh and Arvind Gupta along with WSGR’s Raj Judge at Built With Biology to discuss company building in human & planetary health from inception to iconic. They shared insights on creating built-to-last vs built-to-sell companies, building and designing a platform, mission to market vs mission to science, and more.

Read more >>

VR Meditation Company TRIPP Raises $11M to Build the Mindful Metaverse

XR wellness platform TRIPP has raised $11M to continue building the mindful metaverse that can, in the words of CEO Nanea Reeves, “deepen connection to self, facilitate mental well-being and enable personal and collective transformation.” They have also announced the acquisition of cross-service world-building platform Eden to enable users to further customize their TRIPP experiences.

Read more >>

Introducing the 2022 Mayfield Access for All Summer Fellows

At Mayfield we are committed to investing in relationships to create meaningful opportunities to advance diversity and inclusion in tech. In 2020 we announced our Access for All program, through which we affiliate with leading community organizations to address systemic barriers to opportunity. Since then we’ve pledged 1% of our yearly management fee and carry, partnered with organizations including Neythri, Him For Her and others, and launched our Access for All Summer Fellows Program in collaboration with College Track. 

College Track equips talented scholars from low-income households to be the first in their family to graduate from college, and we’re proud to partner with them on our Access for All Summer Fellows Program. Together we place interns at some of our portfolio companies for career-accelerating opportunities.

Today I’m excited to introduce our 5 fellows for 2022, who will be supporting Immersa, Mammoth Biosciences, Outreach and SeekOut in a variety of roles, including sales, people ops, RevOps, data engineering and diagnostic innovation. Please join me in welcoming the 2021 Mayfield Summer Fellows, and learn a bit more about them below.

 

Samara Benjamin (she/her)

Hometown: Sacramento, CA

University & Major: Delaware State University ‘23, Psychology

Internship: Sales Development Intern, Outreach

I am most excited for building relationships with my sales development team and providing strong customer service. A fun fact about myself is I am a huge San Francisco 49ers fan.” 

 

Daren Cheng (he/him)

Hometown: Oakland, CA

University & Major: San Jose State University ‘24, Industrial and Systems Engineering

Internship: RevOps Intern, Immersa

I am most excited about learning and finally working in person along side a talented and seasoned team. Two fun facts are I love to swim and surf, and McLaren F1 team is my favorite F1 team.” 

 

Hana Fentahun (she/her)

Hometown: Aurora, CO

University & Major: George Washington University ‘23

Internship: People Team Intern, SeekOut

“I’m very excited to gain some experience assisting and observing how various Diversity, Equity, Inclusion, and Belonging initiatives are formed and implemented, as well as organizing and supporting employee engagement events. I was born in Ethiopia and I can speak, read, and write in my native language.”

 

William Ho (he/him)

Hometown: San Francisco, CA

University & Major: UC Santa Cruz ‘25, Computer Science

Internship: Data Engineering Intern, Immersa

“I’m most excited about building data pipelines and just learning more about what a Data Engineer does. Also interested in learning about how a smaller company works compared to a large company. I enjoy playing tennis in my free time and I’ve been playing since the 5th grade.”

 

PeiWen Xiao (she/her)

Hometown: Oakland, CA

University & Major: UC Berkeley ‘23, Bioengineering

Internship: Diagnostic Innovation Intern, Mammoth Biosciences

Through this internship, I am excited to work on and see the translation of concepts I have learned in my classes into tangible tools and technologies that can benefit others. In my free time, I like to draw and paint with different mediums and fold origami cranes.”

 

Congratulations to our fellows – looking forward to a bright future ahead powered by the next generation of tech leaders!

Saving our Planet One Sustainable Battery at a Time

The movement toward electric transportation and renewable energy is rapidly going mainstream and will make a big impact on improving our planetary health. Powering these systems requires a new class of batteries, with the lithium-ion battery market expected to grow from $44 billion in 2021 to $200 billion by 2028. However, the market is heavily supply constrained as new chemistries and better testing processes are required to improve performance and unlock the supply of batteries. We need to accelerate the transition to sustainable energy, sustainably.

Today I am honored to share that we have partnered with Kaixiang Lin, Harvard Ph.D, and Jason Koeller, UC Berkeley Ph.D, two of the world’s best battery innovators, who are the founders of Chemix, an AI-powered platform company that will discover, design and deliver better batteries. In addition to product innovation, a start-up requires a founding team with multiple skills, a capital efficient business model, and the ability to leverage the global ecosystem – and we believe Kaixiang, Jason and their team have true platform potential.  Our journey with them reflects our roots as an early-stage investor, which requires the ability to dream big with founders, an appetite for risk, and the endurance to stay involved in companies throughout their inception to iconic journeys.

I met Kaixiang and Jason a year ago as they had decided to take their learnings from working together at a previous battery start-up to found Chemix.  Inspired by their world-class expertise and unique approach, we partnered with them on their $3.6M pre-seed round in October 2021 and have been working with them since.  Today they are announcing a $7M seed round, led by us along with their pre-seed investors Radical Ventures with participation from new investor Ibex Ventures.  Key operating milestones since their pre-seed stage include defining their business as a complete battery solution provider including cell, pack, and AI-powered cloud-based software to monitor battery field deployments, securing UBCO, a leading EV adventure bike manufacturer, as their first customer/delivery partner with a multi-million-dollar contract, building an automated battery pilot facility, and expanding the team beyond the founders to a dozen domain experts.

We believe Chemix will soon achieve next-gen battery performance 10x faster and cheaper than conventional approach by:

  • Building an AI-guided discovery platform to explore the vast chemical landscape to unlock commercialization potential of all battery chemistries vs. going all-in on one initial chemistry. This is a similar approach to our CRISPR platform portfolio company Mammoth Biosciences.
  • By enabling application specific battery development strategy that enables customers to bring highly differentiated products to market instead of relying on suboptimal off the shelf batteries.
  • By accelerating the testing process through an AI-powered approach that predicts cell life-cycle.
  • By leveraging existing Li-ion manufacturing facilities (GWh level) to produce high‑quality & high-volume cells using the standard cylindrical and pouch cell formats for a high velocity, capital efficient business model.
  • By including the life-time battery health monitoring software with its batteries for xEV OEMs and utilities.

Along with our other human and planetary health investments in precision medicine, new foods and materials, we look forward to enabling entrepreneurs to address the big problems to make our world better for the next generation.  Please join me in welcoming the Chemix team to the Mayfield family.

Precision Immunology Platform Endpoint Health Raises $52M Series A

Engineering Biology Updates: Grifols, Bayer Partnerships, Leadership Spotlight & a POV on Climate Change

Janice Chen, CTO and Co-founder of Our Portfolio Company Mammoth Biosciences, is Spotlighted in CNBC.

In this edition:

  • Precision Immunology Company Endpoint Health Partners with Grifols on Critical Immune System Illness
  • Mammoth Biosciences Receives FDA Emergency Use Authorization for Covid-19 Test, Partners with Bayer to Target Genetic Diseases of the Liver
  • Qventus Announces $50M Growth Financing Enabling Market Presence Expansion
  • Study Published in Nature Proves Mirvie’s RNA Platform Predicts Pregnancy Complications Months Before Symptoms Appear
  • Mammoth Biosciences Expands Leadership Team with the Appointment of Elaine Sun as COO/CFO
  • Arvind Shares his POV on Climate Change, Investment Values and Guiding Principles, Plus Pitch Advice for Founders

Precision Immunology Company Endpoint Health Partners with Grifols on Critical Immune System Illness

Precision immunology platform company Endpoint Health has partnered with Grifols to develop and commercialize an Antithrombin III (AT-III) therapy to treat sepsis. This collaboration marks a huge step towards getting new treatments to market for critical immune system dysfunctions like sepsis that kill more people than all cancers combined.

Read more >>

Mammoth Biosciences Receives FDA Emergency Use Authorization for Covid-19 Test, Partners with Bayer to Target Genetic Diseases of the Liver

Mammoth Biosciences’ ground-breaking CRISPR-based molecular diagnostic system for Covid-19 testing received Emergency Use Authorization from the FDA. Mammoth continues to redefine engineering biology through their new strategic collaboration with Bayer to develop in-vivo gene therapies, starting with diseases of the liver, using Mammoth’s cutting edge CRISPR platform.

Read more >>

Qventus Announces $50M Growth Financing Enabling Market Presence Expansion

Each year the health care system loses approximately $1 trillion to waste, and one major contributor is inefficient operations. Qventus’s AI-enabled care operations automation software tackles this problem head on with proven results. In 2021 alone, Qventus automated access and patient flow for more than 2 million patient encounters, eliminating over 200 years of excess hospital stay days and resulting in a 10X return on investment.

Read more >>

Study Published in Nature Proves Mirvie’s RNA Platform Predicts Pregnancy Complications Months Before Symptoms Appear

Unexpected complications affect one in five pregnancies, and yet today women and doctors lack a reliable way to detect complications before symptoms appear. Mirvie’s proprietary RNA platform is the first of its kind to predict unexpected complications by revealing the underlying biology of each pregnancy. This technology is set to revolutionize pregnancy health by allowing women and their doctors to intervene before underlying issues become health crises.

Read more >>

Mammoth Biosciences Expands Leadership Team with the Appointment of Elaine Sun as COO/CFO

Mammoth Biosciences has appointed Elaine Sun as its new Chief Operating Officer/Chief Financial Officer, marking a notable expansion of its leadership team. Elaine has over 25 years of experience in the life sciences industry and joins from Halozyme, a biotechnology company that develops novel oncology therapies.

Read more >>

Arvind Shares his POV on Climate Change, Investment Values and Guiding Principles, Plus Pitch Advice for Founders

Arvind shares his stance on morality in investment and shares how his personal experiences keep him grounded on his mission to improve and save lives through investing in planetary health. Arvind also recently shared some candid pitch advice for first time founders and where he’s looking for the next iconic companies.

Learn more >>